Journal of Nanomedicine & Nanotechnology

Kazuhisa Sugimoto

Publications

• Research Article
  A Novel Nano-Capsule of a-Lipoic Acid as a Template of Core-Shell Structure Constructed by Self-Assembly
  Author(s): Hiromi Nishiura, Kazuhisa Sugimoto, Kaori Akiyama, Mina Musashi, Yoshiki Kubota, Tomonori Yokoyama, Yuji Yamashita, Takashi Kuriki and Yoko YamaguchiHiromi Nishiura, Kazuhisa Sugimoto, Kaori Akiyama, Mina Musashi, Yoshiki Kubota, Tomonori Yokoyama, Yuji Yamashita, Takashi Kuriki and Yoko Yamaguchi
  
  Mast cells (MC) and peripheral blood basophils (PBB) are well known for their role in the allergic response mediated through high affinity IgE receptors (FcεRI). However, these cells can also be stimulated by other non-allergic secretagogues to release their inflammatory mediators. Certain fullerene derivatives (FD) have already been shown to stabilize FcεRI-mediated MC/PBB responses, but it is not know if they also stabilize these cells through non-IgEmediated mechanisms. A panel of FD was synthesized and tested for their ability to inhibit non-FcεRI mediated release from human MC and PBB. It was found that specifically engineered FD could significantly inhibit calcium ionophore, compound 48/80, somatostatin, and poly L-lysine induced MC degranulation and cytokine production, as well as blunt degranulation and cytokine production from N-formyl-methionine-leuci.. View More»
  DOI: 10.4172/2157-7439.1000155

  Abstract PDF