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Katy Rutledge
Katy Rutledge
Tanzania
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Research Article
Nanoengineered Platforms to Guide Pluripotent Stem Cell Fate
Author(s): Katy Rutledge and Ehsan JabbarzadehKaty Rutledge and Ehsan Jabbarzadeh
Tissue engineering utilizes cells, signaling molecules, and scaffolds towards creating functional tissue to repair damaged organs. Pluripotent stem cells (PSCs) are a promising cell source due to their ability to self-renewal indefinitely and their potential to differentiate into almost any cell type. Great strides have been taken to parse the physiological mechanisms by which PSCs respond to their microenvironment and commit to a specific lineage. The combination of physical cues and chemical factors is thought to have the most profound influence on stem cell behavior, therefore a major focus of tissue engineering strategies is scaffold design to incorporate these signals. One overlooked component of the in vivo microenvironment researchers attempt to recapitulate with three dimensional (3D) substrates is the nanoarchitecture formed by the fibrillar network of extracellular matrix (E.. View More»
DOI: 10.4172/2157-7439.1000217