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Katy E Rutledge
Katy E Rutledge
Tanzania
Publications
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Research Article
Modulation of Inflammatory Response and Induction of Bone Formation Based on Combinatorial Effects of Resveratrol
Author(s): Katy E Rutledge, Qingsu Cheng and Ehsan JabbarzadehKaty E Rutledge, Qingsu Cheng and Ehsan Jabbarzadeh
The success of bone tissue engineering strategies critically depends on the rapid formation of a mature vascular network in the scaffolds after implantation. Conventional methods to accelerate the infiltration of host vasculature into the scaffolds need to consider the role of host response in regulation of bone tissue ingrowth and extent of vascularization. The long term goal of this study was to harness the potential of inflammatory response to enhance angiogenesis and bone formation in three dimensional (3D) scaffolds. Towards this goal, we explored the use of resveratrol, a natural compound commonly used in complementary medicine, to enable the concurrently (i) Mediate M1 to M2 macrophage plasticity, (ii) Impart natural release of angiogenic factors by macrophages and (iii) Enhance osteogenic differentiation of human mesenchymal stem cells (hMSCs). We .. View More»
DOI: 10.4172/2157-7439.1000350