Biology and Medicine

Katsuhiko Suzuki

Publications

• Review Article
  Systemic Inflammation Mediates the Effects of Endotoxemia in the Mechanisms of Heat Stroke
  Author(s): Chin Leong Lim and Katsuhiko SuzukiChin Leong Lim and Katsuhiko Suzuki
  
  Heat stroke is triggered by heat, but is driven by endotoxemia and the downstream effects of systemic inflammation, acute phase response and the pyrogenic response. Whereas heat stroke and its related fatality commonly occur at core temperature (Tc) >40°C, healthy individuals have tolerated Tc 40°C-42°C without symptoms of heat stroke, suggesting that besides hyperthermia, there are other factors that can also cause heat stroke. The “Dual-pathway model (DPM)” suggests that heat stroke is triggered by the endotoxemia pathway at Tc up to ~ 42°C and independently, by heat toxicity at Tc >42°C. The second pathway in the DPM is based on evidence showing that cytoskeletal structures start to disintegrate at ambient temperature >41.5°C. Since most exertional stroke cases occur at Tc <42°C, the endotoxemia pathway, and not heat, might be the.. View More»
  DOI: 10.4172/0974-8369.1000376

  Abstract PDF