Journal of Vascular Medicine & Surgery

Kathryn N Schaefer

Publications

• Research Article
  Differences in Inflammatory Cytokine Levels between Patients with Varying Severity of Chronic Venous Insufficiency
  Author(s): Lark G Guss, Srimanasi Javvaji, Jamie Case, Bethany Barrick BS, Kathryn N Schaefer, Ryan Gilbertson BS, Jill Waalen5, Hugh T Greenway and Leland B HousmanLark G Guss, Srimanasi Javvaji, Jamie Case, Bethany Barrick BS, Kathryn N Schaefer, Ryan Gilbertson BS, Jill Waalen5, Hugh T Greenway and Leland B Housman
  
  Objective: Several studies have found that protein concentrations of inflammatory cytokines are significantly increased in tissue and serum from patients with chronic venous insufficiency (CVI) relative to that of healthy controls. We sought to determine whether inflammatory protein concentrations differ between patients with moderate clinical disease, classified as clinical, etiology, anatomy, pathophysiology (CEAP) Classes 2 and 3, and more severe clinical disease, classified as CEAP Class 4. Methods: Twenty patients with abnormal venous function were included in the study. Blood from a competent leg vein and from an incompetent superficial vein was collected in addition to incompetent vein tissue extracted through a phlebectomy procedure. Cytokine levels of venous tissue lysate and serum samples were determined u.. View More»
  DOI: 10.4172/2329-6925.1000363

  Abstract PDF