Journal of Bioequivalence & Bioavailability

Karthick N

Publications

• Research Article
  Neurobehavioral Alterations and Brain Creatine Kinase System Changes in Chronic Renal Failure Induced Male Wistar Rats: Impact of Erythropoietin Supplementation
  Author(s): Karthick N, Alwin D, Poornima KN, Chitra V, Saravanan A, Balakrishnan D and Venkataraman PKarthick N, Alwin D, Poornima KN, Chitra V, Saravanan A, Balakrishnan D and Venkataraman P
  
  Chronic renal failure (CRF) is a rapidly growing global health problem and it causes anaemia and cognitive impairment. Recombinant Human erythropoietin (rHu-Epo) has been a promising role in the management of anaemia in CRF subjects and it is well documented. It also shown as a remarkable neuroprotection in both cell cultures and in animal models. Creatine kinase (CK) plays a key role in energy metabolism and its activity found in cytoplasm of several human tissues; major sources of CK include skeletal muscle, myocardium and brain. Studies show brain energy metabolism is key to neuronal cell function and cognitive health. The aim of this study is to investigate the impact of rHu-Epo on CRF induced changes in CK system in serum and brain regions of experimental animals and to test its significance in neurobehavioral changes. Experimental design is divided into two phases to find out th.. View More»
  DOI: 10.4172/jbb.1000218

  Abstract PDF