Journal of Microbial & Biochemical Technology

Karen Perelmuter

Publications

• Research Article
  Forkhead Box Protein O1 is Linked to Anti-Inflammatory Probiotic Bacteria Acting through Nuclear Factor-κB Pathway
  Author(s): Ana Paula Mulet, Karen Perelmuter, Mariela Bollati-Fogolin, Martina Crispo and Gianfranco GromponeAna Paula Mulet, Karen Perelmuter, Mariela Bollati-Fogolin, Martina Crispo and Gianfranco Grompone
  
  Probiotics are widely used to promote health benefits around the world. Nevertheless, the mechanisms whereby probiotics exert its beneficial effect on the host are not well elucidated yet. In an attempt to obtain relevant insights on probiotics mechanisms of action, we studied the probiotic response via Nuclear factor-κB (NF-κB) and Forkhead box protein O1 (FoxO1), two transcription factors that were previously related with probiotic effects. We performed in vitro analysis to activate these transcription factors with Tumor Necrosis Factor alpha (TNFα) and Hydrogen Peroxide (H2O2) stimuli using a set of probiotic strains co-cultured with HT-29 cells. We found three strains, LrBPL8, LcA1 and LaBPL71 capable to reducing the NF-κB activation pathway in an inflammatory context. We also found that LcA1 reduced FoxO1 activation while another strain, IPM C+, increased .. View More»
  DOI: 10.4172/1948-5948.1000347

  Abstract PDF