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Kang Joon Lee
Kang Joon Lee
Ilsanpaik Hospital, Inje University College of medicine,
170, Juhwa-ro, Ilsanseo-gu, Goyangsi, Gyeonggi-do, 411-706
Publications
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Research Article
Differences in BDNF Serum Levels in Patients with Alzheimer?s Disease and Mild Cognitive Impairment
Author(s): Hyun Woo Shin, Hyun Kim and Kang Joon LeeHyun Woo Shin, Hyun Kim and Kang Joon Lee
Objectives: A great deal of research has been conducted into the possible involvement of neurotrophins such as brain-derived neurotrophic factor (BDNF) in the pathogenesis of Alzheimer’s disease (AD). We hypothesized that lower BDNF serum levels may be associated with cognitive decline. To test this hypothesis, we examined the differences in the serum BDNF levels in patients with AD and mild cognitive impairment (MCI) and normal controls. Method: We enrolled 56 subjects with AD, 29 subjects with MCI, and 24 healthy control subjects in the study. A total of 109 subjects agreed to blood sampling to evaluate serum BDNF levels. Serum levels of BDNF were measured using an enzyme-linked immunosorbent assay (ELISA) method. Results: The MCI group had higher BDNF levels as compared to the AD group (p=0.027). However, ther.. View More»
DOI: 10.4172/Psychiatry.1000245