Journal of Nanomedicine & Nanotechnology

Kai Griebenow

Publications

• Research Article
  Redox-Sensitive Cross-Linking Enhances Albumin Nanoparticle Function as Delivery System for Photodynamic Cancer Therapy
  Author(s): Anna M Molina, Moraima Morales-Cruz, Marimar Benítez, Kiara Berríos, Cindy M Figueroa and Kai Griebenow Anna M Molina, Moraima Morales-Cruz, Marimar Benítez, Kiara Berríos, Cindy M Figueroa and Kai Griebenow
  
  Photodynamic cancer therapy is still limited in its efficiency because of a lack of targeted methods avoiding nonspecific toxicity. To overcome this we developed a system that is solely effective upon cellular uptake and intracellular activation by incorporating redox-sensitive chemistry. We used a nanoprecipitation method to obtain human serum albumin nanoparticles (HSA NP) with a diameter of 295 ± 5 nm and decorated them with the photosensitizer (PS) chlorin e6 (Ce6). The NP was stabilized using a redox-sensitive cross-linker to create a smart drug delivery system that is activated only upon NP disintegration in the reducing intracellular environment. Indeed, our drug delivery NP broke down in an environment emulating the reducing intracellular environment with 10 mM glutathione, but not under extracellular conditions. In contrast, the control cross-linked wi.. View More»
  DOI: 10.4172/2157-7439.1000294

  Abstract PDF