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Jyothy John
Jyothy John
Tanzania
Publications
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Review Article
Oral Liquid Formulation of Etravirine for Enhanced Bioavailability
Author(s): Jyothy John and Dong LiangJyothy John and Dong Liang
Aim: Etravirine is the first drug in the second generation of Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs). Despite its use in clinical management of HIV infected patients, the drug has very limited bioavailability due to low water solubility and low gastrointestinal permeability. The majority of currently available anti-AIDS drugs in the U.S. market are in solid dosage forms. There is a need of introducing an oral liquid dosage formulation, especially for those AIDS patients who are often unable to swallow a pill. Methods: Co-solvent formulations of etravirine were prepared using 1-methyl-2-pyrrolidinone, Labrasol, and water after evaluating the etravirine solubility in various solvents. A long term stability study was carried out to examine the physical stability of an optimal oral formulation of etravirine. Pharmacokinetic studiesof etravirine were conducted in rats to .. View More»
DOI: 10.4172/jbb.1000179