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Julie IvanaJay
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Research Article
The Cooperative Anticancer Effect of Dual Styrenemaleic Acid Nano- Miceller System against Pancreatic Cancer
Author(s): Khaled Greish, Katherine Muller, Julie IvanaJay and Don Haeng LeeKhaled Greish, Katherine Muller, Julie IvanaJay and Don Haeng Lee
Pancreatic tumors remain one of the most formidable cancer types to treat. Patients with locally advanced or metastatic disease, which collectively represent over 80% of patients, rarely survive beyond one year. Pancreatic cancer is especially difficult to treat because of the uniqueness of its histology, with few vasculatures that can be used to supply anticancer agents. In this work we test a new system made of two styrene maleic acid (SMA) Nanomiceles encapsulating the phototosensetizer Zinc Protoporphyrin (ZnPP) or anticancer agent 4’-O-tetrahydropyranyl - doxorubicin (THP/Pirarubicin). Our hypothesis is that, local inflammatory response in tumor vessels induced by photosensitization can improve anticancer drug delivery and hence the anticancer activity. Two pancreatic tumor cell lines (Panc-1 and ASPC-1) were used to test the synergism o.. View More»
DOI: 10.4172/2157-7439.S4-004