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Jostein Halgunset
Jostein Halgunset
Norway
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Review Article
Inhibitors of Tyrosine Kinases (TKI) and Small Interfering RNAs (siRNA) are Promising Targeted Cancer Treatments
Author(s): Haakon Skogseth, Kåre E. Tvedt and Jostein HalgunsetHaakon Skogseth, Kåre E. Tvedt and Jostein Halgunset
Background: In recent years, many investigators have focused on the development of drugs with the potential to influence the malignant phenotype. Clearly, our understanding of molecular and cellular processes behind such mechanisms has increased substantially through the past decades. This knowledge has led to an extensive search for targeted carcinoma treatment.Methods: This review is based on a qualified selection of articles published in internationally recognized journals. Some considerations are also based on the authors’ own experience in clinical and molecular-targeted basic research.Results: Inhibitors of tyrosine kinases (TKIs) and selective gene expressional regulators, small interfering RNAs, give hope for advances in the treatment of various carcinomas. However, it seems clear that the main challenge also.. View More»
DOI: 10.4172/2157-2518.1000122