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Jie Li
Jie Li
Indiana
Publications
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Research Article
Effect of IL-12 on Experimental Allergic Otitis Media with Effusion
Author(s): Jie Li, Shouqin Zhao*, Yubin Xue, Ying Li and Chenyi Wei Jie Li, Shouqin Zhao*, Yubin Xue, Ying Li and Chenyi Wei
Objective: To investigate the role of IL-12 in the pathogenesis of Otitis media with effusion (OME) in animal model induced by ovalbumin. Methods: Twenty-four Sprague-Dawley (SD) rats were randomly divided into three group as OME group, IL-12 group, and control group. The rats of OME group were sensitized to OVA via intraperitoneal injection once a week for two weeks and then challenged transtympanic. The rats of IL-12 group and control group were sensitized and challenged in the same way, but before challenge they were injected IL-12 and PBS transtympanic respectively. The histomorphologic changes of middle ear mucosa were observed with histochemical technique. The level of IL-4 and IL-5 was measured by immunohistochemistry. Results: Tympanal mucosa in OME group and control group .. View More»
DOI: 10.4172/2167-7182.1000342