Journal of Stem Cell Research & Therapy

Jian Zhang

Publications

• Research Article
  Histone Deacetylase Inhibitors can Repress Proliferation and Induce Apoptosis in Gingiva Progenitor Cells from Idiopathic Gingival Fibromatosis
  Author(s): Zhi Jia, Chunyue Feng, Yingchenyao Wang, Jingkun Li, Tingting Zhang, Jian Zhang and Dayong Liu Zhi Jia, Chunyue Feng, Yingchenyao Wang, Jingkun Li, Tingting Zhang, Jian Zhang and Dayong Liu
  
  Objective: Idiopathic gingival fibromatosis (IGF), which is characterized by diffuse enlargement of the gingiva due to expansion and accumulation of connective tissue, is a relatively rare hereditary condition that has no specific cause. The aim of this study was to investigate whether the anti-tumor drugs trichostatin A (TSA; inhibits histone deacetylase) and panobinostat (LBH589; a non-selective inhibitor of histone deacetylase) inhibit the proliferation of cells derived from gingiva in patients with IGF. Materials and methods: After osteogenic differentiation and adipogenic induction, the differences between normal gingival mesenchymal stem cells ( N-GMSCs ) and hyperplastic gingival mesenchymal stem ( H-GMSCs, theI cells from IGF ) were determined in terms of alkaline phosphatase staining and activity, alizarin red staining.. View More»
  DOI: 10.4172/2157-7633.1000327

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