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Jennifer M Connolly
Jennifer M Connolly
Ireland
Publications
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Research Article
Nanogold-based Photosensitizers Probes for Dual-model Bioimaging and Therapy of Cancer
Author(s): Jennifer M Connolly, Vijay Raghavan, Peter Owens, Antony Wheatley, Ivan Keogh, Peter Dockery and Malini OlivoJennifer M Connolly, Vijay Raghavan, Peter Owens, Antony Wheatley, Ivan Keogh, Peter Dockery and Malini Olivo
Reported here is the use of novel nanogold based photosensitisers (nanosensitisers) as optical diagnostic probes and as potential photodynamic and photothermal cancer therapeutic agents using an in vitro cancer cell model. Such multimodal nanosensitisers were constructed by layering photosensitisers (Hypericin, Chlorin e6) onto multi-branched gold nanoparticles. Nanosensitisers were conjugated to tumour-specific antibodies to confer cancer-cell specificity. Both oral (SCC9) and breast cancer (MCF7) cell lines were cultured in vitro with various concentrations of nanosensitisers. Cellular uptake and intracellular localisation of nanosensitisers was assessed using darkfield contrast imaging, transmission electron microscopy and Raman spectroscopy imaging and quantified using confocal fluorescence microscopy. In addition to photodynamic diag.. View More»
DOI: 10.4172/2157-7439.1000249