Journal of Stem Cell Research & Therapy

Jean-Jacques Candelier

Publications

• Research Article
  A Population of Human Mesenchymal Stem Cells Specific to the Fetal Liver Development
  Author(s): Wenwei Zhang, Zahia Hamidouche, Guillaume Pourcher, Varvara Gribova, Farhad Haghighi, Jean-Jacques Candelier, Pierre Charbord and Anne Dubart-Kupperschmitt Wenwei Zhang, Zahia Hamidouche, Guillaume Pourcher, Varvara Gribova, Farhad Haghighi, Jean-Jacques Candelier, Pierre Charbord and Anne Dubart-Kupperschmitt
  
  Mesenchymal Stem Cells (MSCs) with osteoblastic/chondrocytic potential have been detected in different anatomical sites including the Fetal Liver (FL). The puzzling presence of such cells in FL led us to investigate whether they displayed additional differentiation competence compatible with their location at this developmental stage. This study has resulted in the successful isolation of a population of clonogenic cells from 11-12 gestational week human fetal livers that spontaneously differentiated into vascular smooth muscle cells during the proliferative phase. The cells were also able to differentiate into adipocytes, osteoblasts and chondrocytes, but only when submitted to specific culture conditions. Moreover, the isolated population expressed hepatocytic transcription factors. The analysis of FL sections suggested that the clones generated in .. View More»
  DOI: 10.4172/2157-7633.1000238

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