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Jayanta Kumar Pandit
Jayanta Kumar Pandit
IT, Banaras Hindu University, Varanasi-221005, Uttar Pradesh,
India
Publications
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Research Article
Preparation and Characterization and Biodistribution Studies of Lomustine Loaded PLGA Nanoparticles by Interfacial Deposition Method.
Author(s): Archana Mehrotra and Jayanta Kumar PanditArchana Mehrotra and Jayanta Kumar Pandit
The incorporation of lomustine, a hydrophobic anticancer drug into PLGA nanoparticles by interfacial deposition method was optimized. Based on the optimal parameters, it was found that lomustine-PLGA nanoparticles with acceptable properties could be obtained. Optimization of formulation variables to control the size and drug entrapment efficiency of the prepared nanoparticles seems to be based on the same scientific principles as drug-loaded nanoparticles prepared by nanoprecipitation, solvent evaporation method. The process was the most important factor to control the particle size, while both the drug-polymer interaction and the partition of drug in organic and aqueous phases were the crucial factors to govern the drug entrapment efficiency. PLGA concentration at lower level (100 mg), 1:5 organic phase: aqueous ratio, 1%w/v PVA concentration, 3%w/v pluro.. View More»
DOI: 10.4172/2157-7439.1000328