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Ivan Keogh
Ivan Keogh
Ireland
Publications
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Research Article
Gold Nanosensitisers for Multimodal Optical Diagnostic Imaging and Therapy of Cancer
Author(s): Vijay Raghavan, Jennifer M Connolly, Hai Ming Fan, Peter Dockery, Antony Wheatley, Ivan Keogh and Malini OlivoVijay Raghavan, Jennifer M Connolly, Hai Ming Fan, Peter Dockery, Antony Wheatley, Ivan Keogh and Malini Olivo
Multi-modal nanoprobes have attracted much attention because of their superior chemical and physical properties that have great potential for early diagnosis and treatment of cancer. We report herein a novel stepwise fabrication of a gold nanoparticle-Raman reporter-photosensitiser conjugate called a Gold Nanosensitiser (NS). The efficacy of gold NS as multimodal nanoprobes for surface enhanced Raman spectroscopy (SERS) imaging and photodynamic (PDT) and photothermal treatment (PTT) of cancer were examined. NS were constructed using a multilayer technique in which a Raman reporter, DTTCI (3,3’-Diethylthiatricarbocyanine iodide) and a photosensitiser, hypericin, were coated onto gold nanostars. By adjusting the layer spacing, these coatings endowed NS with both enhanced SERS and fluorescence bioimaging capabilities. Excitation of the NS in solution at.. View More»
DOI: 10.4172/2157-7439.1000238