PMC/PubMed Indexed Articles
Indexed In
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- JournalTOCs
- ResearchBible
- China National Knowledge Infrastructure (CNKI)
- Scimago
- Ulrich's Periodicals Directory
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- MIAR
- Scientific Indexing Services (SIS)
- Euro Pub
- Google Scholar
Useful Links
Share This Page
Journal Flyer
Open Access Journals
- Agri and Aquaculture
- Biochemistry
- Bioinformatics & Systems Biology
- Business & Management
- Chemistry
- Clinical Sciences
- Engineering
- Food & Nutrition
- General Science
- Genetics & Molecular Biology
- Immunology & Microbiology
- Medical Sciences
- Neuroscience & Psychology
- Nursing & Health Care
- Pharmaceutical Sciences
Iti Som
Iti Som
India
Publications
-
Research Article
Haloperidol Loaded Solid Lipid Nanoparticles for Nose to Brain Delivery: Stability and In vivo Studies
Author(s): Mohd Yasir, UVS Sara and Iti SomMohd Yasir, UVS Sara and Iti Som
In the present study, Haloperidol loaded solid lipid nanoparticles were prepared to enhance its uptake to brain via intranasal route. SLNs were prepared by modified emulsification diffusion technique. For optimization, a three factors and three levels Box - Behnken design was applied to study the effect of independent variables (factors) i.e. drug to lipid ratio (A), surfactant concentration (B) and stirring speed (C) on dependent variables (responses) i.e. particles size (Y1), entrapment efficiency (Y2), and drug loading (Y3). The value of optimized variables for HP-SLNs was 1:2 (drug to lipid ratio), 1.625% (surfactant concentration) and 3000 rpm (stirring speed). The optimized HP-SLNs formulation was evaluated for stability and in vivo studies. Stability studies revealed no significant (P<0.5) change was observed in particle size, zeta potential, ent.. View More»
DOI: 10.4172/2157-7439.S7-006