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Journal of Bioequivalence & Bioavailability

Issa YM

Issa YM

Egypt

Publications
  • Research Article
    Novel Coated Wires Sensors with Flow-Injection for Potentiometric Determination of Neostigmine in Bulk, Amostigmine and Human Urine
    Author(s): Khorshid AF and Issa YMKhorshid AF and Issa YM

    Four types of coated wires sensors (silver, copper, graphite and glassy carbon) are constructed for the determination of neostigmine (Ns) based on the ion-pair associates neostigmine silicotungstate (Ns-ST), neostigmine silicomolybdate (Ns-SM), neostigmine phosphotungstate (Ns-PT), neostigmine phospho molybdate (Ns-PM),and ion-pairs neostigmine tetraphenylborate (Ns-TPB) in a poly (vinyl chloride) as coated film with a plasticized tricresylphthalate (TCP). The four types sensors are showed a Nernstain slopes ranged from 59-64 mV per decade in batch and 65-70 mV per decade in flow injection conditions (FIA) over a neostigmine concentration ranged from 5.0x10-7-1.0x10-2 M and within the pH range 4.0-11.0. The influences of coated film composition, pH of the Ns and foreign ions on the sensors performance were investigated and were found to be very selective, precise and excellent selecti.. View More»
    DOI: 10.4172/jbb.1000227

    Abstract PDF