Journal of Carcinogenesis & Mutagenesis

Isidora Ranchal

Publications

• Research Article
  Olive Leaves and Mill Waste Exert Anti-Tumoral Properties in Hepatoma Cell Line
  Author(s): Isidora Ranchal, María D Luque de Castro and Jordi MuntanéIsidora Ranchal, María D Luque de Castro and Jordi Muntané
  
  Different phenolic compounds such as oleuropein and hydroxytyrosol have demonstrated antitumoral activity in cancer cell lines. Olive derivatives have demonstrated beneficial properties in cardiovascular diseases. The study was addressed to show the potential beneficial properties of olive leaves and olive oil mill waste extracts in hepatoma cell lines. Aflatoxin B1 (AFB1) was administered to hepatoma cell line (HepG2). Different parameters related to cell death, cell proliferation and DNA damage were determined. The expression of p53 and c-Src (activated and inhibitory phosphorylated state) was assessed by Western blot analysis in HepG2. The olive leaves and olive oil mill waste extracts contained oleuropein and hydroxytyrosol, respectively. AFB1 induced cell proliferation and death, associated to a rise on p53 and c-Src expression in HepG2 cells. Oleuropein and hydroxytyrosol reduce.. View More»
  DOI: 10.4172/2157-2518.1000170

  Abstract PDF