Journal of Carcinogenesis & Mutagenesis

Ishita Gupta

Publications

• Review Article
  Micrometastatic Circulating Tumor cells - A Challenge for an Early Detection and Better Survival Rates
  Author(s): Yahya Tamimi, Ishita Gupta, Mansour Al-Moundhri and Ikram Burney Yahya Tamimi, Ishita Gupta, Mansour Al-Moundhri and Ikram Burney
  
  Micrometastasis is a health burden affecting a large population worldwide, where early stage circulating tumor cells are clinically below the detection limit of the currently used techniques in diagnosis. These cells are considered one of the sources related to the disease spread, usually associated with poor prognosis and resistant to conventional therapies. With the recent advances in technology, various molecular and biological techniques including cytological examination, RT-PCR immunocytochemistry, immuno-magnetic separation and cell-enrichment techniques have emerged to improve the early detection of circulating tumor cells in different carcinomas. However, the sensitivity and specificity of these techniques along with their prognostic influence are still contested. This review aims to discuss the role of key player molecules including cell adhesion molecules, integrins and prot.. View More»
  DOI: 10.4172/2157-2518.1000229

  Abstract PDF