Journal of Liver

Ishii K

Publications

• Research Article
  Amino Acid 70 Substitution in the Core Region of Hepatitis C Virus in Serum Lipid Markers of Patients with Chronic Hepatitis C Genotype 1b
  Author(s): Kanayama K and Ishii K Kanayama K and Ishii K
  
  Introduction: Previously, we reported that Hepatitis C Virus (HCV) infection had effects for lipid metabolism in patients with Chronic Hepatitis C (CHC). Recently, HCV with substitutions in amino acids (aa) 70 and/or 91 in the core region of HCV (HCV-C) has been reported to be more difficult to treat than HCV without aa 70 and 91 substitutions. The aim of this study was to clarify whether aa 70 or 91 substitution in the HCV-C influenced serum cholesterol fractions in patients with CHC genotype 1b and high viral load. Patients and Methods: Twenty-two patients infected with genotype 1b and high viral loads, whose serum samples taken before the start of therapy had been stored at -80°centigrade, and in whom aa 70 and 91 substitutions in the HCV-C could be detected, were selected. Patients without aa 70 and 91 substitutions in the HCV-C were.. View More»
  DOI: 10.4172/2167-0889.1000152

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