Journal of Bioequivalence & Bioavailability

Ioana Stanescu

Publications

• Research Article
  A Single Dose, Four-Way, Open-Label Bioavailability Study of Oral Acetaminophen and Ibuprofen Combinations (Maxigesic^®) under both Fasting and Fed Conditions
  Author(s): Phillip Aitken, Isam I Salem, Ioana Stanescu, Rebecca Playne and Hartley C AtkinsonPhillip Aitken, Isam I Salem, Ioana Stanescu, Rebecca Playne and Hartley C Atkinson
  
  The use of fixed-dose combination pain relief has the potential to enhance analgesic efficacy. The pharmacokinetic properties of oral medication can be altered by many factors, including food, concomitant medications, and drug formulation. During the present study the pharmacokinetic parameters of an acetaminophen and ibuprofen combination was tested in four formulations. Testing was performed in two clinical trials examining either fasting or fed dosing conditions in healthy male participants. Both trials were single center, open-label, randomized, single dose studies with a four-way crossover design to compare an oral suspension product, a sachet product, and two different tablet formulations (FDC500/150 and FDC325/97.5). Each dose contained acetaminophen 975-1000 mg and ibuprofen 292.5-300 mg. A total of 26 participants completed the fasting study, while 28 completed the fed study... View More»
  DOI: 10.4172/0975-0851.1000383

  Abstract PDF