Journal of Nanomedicine & Nanotechnology

Ildikó Y Tóth

Publications

• Research Article
  Hemocompatibility and Biomedical Potential of Poly(Gallic Acid) Coated Iron Oxide Nanoparticles for Theranostic Use
  Author(s): Márta Szekeres, Erzsébet Illés, Christina Janko, Katalin Farkas, Ildikó Y Tóth, Dániel Nesztor, István Zupkó, Imre Földesi, Christoph Alexiou and Etelka Tombácz Márta Szekeres, Erzsébet Illés, Christina Janko, Katalin Farkas, Ildikó Y Tóth, Dániel Nesztor, István Zupkó, Imre Földesi, Christoph Alexiou and Etelka Tombácz
  
  Polyacid covered core-shell iron oxide nanoparticles were designed for potential use in biomedicine with special attention to theranostics - magnetic resonance imaging (MRI), magnetic hyperthermia and magnetic drug targeting. The magnetite nanoparticles coated with a gallic acid shell polymerized in situ on the nanoparticle surface (PGA@MNPs) were tested for hemocompatibility in blood, sedimentation rate, blood smear and blood cell viability experiments and for antioxidant capacity in Jurkat cells in the presence of H2O2 as reactive oxygen species. No signs of interaction of the nanoparticles with whole blood cells were found. In addition, the PGA@MNPs reduced significantly the oxidative stress mediated by H2O2 supporting earlier findings of MTT tests, namely, the improvement of cell viability in th.. View More»
  DOI: 10.4172/2157-7439.1000252

  Abstract PDF