Biochemistry & Analytical Biochemistry

Igwe CU

Publications

• Research Article
  Biochemical and Haematological Studies on the Ethanol Leaf Extract of Spondias mombin Linn
  Author(s): Igwe CU, Onwuliri VA, Osuagwu CG, Onyeze GOC and Ojiako OAIgwe CU, Onwuliri VA, Osuagwu CG, Onyeze GOC and Ojiako OA
  
  Spondias mombin Linn (Anacardiaceae) is an edible plant that is ethnopharmacologically used for induction of labour, expulsion of afterbirth, and stabilization of women after childbirth. The effects of ethanol extract of the leaf of S. mombin on hepatic, renal and haematologic function indices of albino rabbits were studied using standard methods. Acute toxicity studies of the extract showed the lethal dose (LD 50 ) to be indeterminate, while the effective (abortifacient) dose (ED 50 ) was 753.96 ±0.10 mg/kg body weight. Intraperitoneal administration of 750 mg/kg body weight of the extract significantly (p<0.05) reduced serum alanine aminotransferase and aspartate aminotransferase activities, as well as the serum concentrations of total bilirubin, urea and creatinine, but increased the serum concentrations of total protein, albumin an.. View More»
  DOI: 10.4172/2161-1009.1000104

  Abstract PDF