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Ibrahim M El-Sherbiny
Ibrahim M El-Sherbiny
Zewail City of Science and Technology, 6th of October City, 12588 Giza
Egypt
Publications
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Research Article
Evaluation of Anti-Cancer Potential of Capsaicin-Loaded Trimethyl Chitosan-Based Nanoparticles in HepG2 Hepatocarcinoma Cells
Author(s): Islam E Elkholi, Noha M Hazem, Wagdi F ElKashef, Mohamed A Sobh, Dalia Shaalan, Mohamed Sobh and Ibrahim M El-SherbinyIslam E Elkholi, Noha M Hazem, Wagdi F ElKashef, Mohamed A Sobh, Dalia Shaalan, Mohamed Sobh and Ibrahim M El-Sherbiny
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy characterized by its high resistance to chemotherapeutic agents leading to high morbidity and mortality rates. Capsaicin, the active ingredient of hot peppers, has been reported for its potential as an active anti-cancer agent. In this study, we hypothesized that incorporating capsaicin into nanocarriers might improve its pharmacokinetics. As a result, densely dispersed capsaicin-loaded trimethyl-chitosan nanoparticles (CL-NPs) were developed and their anti-tumor effect was investigated in comparison with capsaicin on human HepG2 cells. The CL-NPs were obtained via iontropic gelation of cationic trimethyl chitosan (TMCS). Both synthesized TMCS and TMCS-based nanoparticles were characterized using zeta analyzer, nanosizer, and TEM. Human hepatoma cell line (HepG2) were cultured then divided in.. View More»
DOI: 10.4172/2157-7439.1000240