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Hui Sun
Hui Sun
China
Publications
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Research Article
Liuwei Dihuang Wan, A Traditional Chinese Medicinal Formula, Protects Against Osteoporosis
Author(s): Hui Sun, Li - jing Li, Ai - hua Zhang, Ning Zhang, Wen - jun Sun and Xi-jun Wang Hui Sun, Li - jing Li, Ai - hua Zhang, Ning Zhang, Wen - jun Sun and Xi-jun Wang
The treatment and prevention of osteoporosis involve great challenges. Liuwei Dihuang Wan (LW), a classic Chinese medicinal formula, has been widely used for clinically treating ?kidney deficiency? in Asia, however, its potency in osteogenesis remains unknown. The purpose of this study is to systemically investigate the effects of LW on ovariectomy-induced osteoporosis in rats. A total of forty-eight 7-month-old female Wistar rats were used and randomly divided into sham-operated group and three ovariectomized (OVX, model) groups: OVX with vehicle; OVX with LW; OVX with nilestriol. Daily oral administration began 4 weeks after the surgery and lasted for 24 weeks. The bone mineral density (BMD), bone mineral content (BMC), uterine index, blood mineral levels and biochemical markers were examined in LW orally treated rats. The trabecular bone micro architecture was also evaluated by MicroC.. View More»
DOI: 10.4172/2153-2435.1000226