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Hoskins C
Hoskins C
United Kingdom
Publications
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Research Article
Investigation into Drug Solubilisation Potential of Sulfonated Calix[4]Resorcinarenes
Author(s): Hoskins C, Papachristou A, Ho TMH, Hine and Anthony CurtisHoskins C, Papachristou A, Ho TMH, Hine and Anthony Curtis
Increasing importance is being placed on the role of drug solubilisation in the drug development pipeline. In order for drugs to successfully pass through the pre-clinical studies required before clinical trials they often require addition of excipients or solubility modifying agents. This study highlights the use of sulfonated calix(4) resorcinarenes as drug solubilising agents. The rigid nature of these compounds form cone-like structures with hydrophobic interiors which are capable of accommodation of hydrophobic entities such as drugs. The calix (4)resorcinarenes in this work have varied length of alkyl chains attached to their lower rim. This work investigated the effect of chain length (C = 4 (SC(4)RC4), C = 7 (SC(4)RC7)) on the degree of solubilisation of two model hydrophobic drugs: propofol and griseofulvin. The data showed that the compounds were.. View More»
DOI: 10.4172/2157-7439.1000370