Journal of Allergy & Therapy

Hitome Kobayashi

Publications

• Research Article
  Suppressive Activity of Histamine H1 Receptor Antagonists, Desloratadine and Levocetirizine, on the Production of Periostin from Nasal Epithelial Cells In vitro
  Author(s): Masayo Asano, Tomomi Mizuyoshi, Shintaro Ishikawa, Kazuhito Asano and Hitome Kobayashi Masayo Asano, Tomomi Mizuyoshi, Shintaro Ishikawa, Kazuhito Asano and Hitome Kobayashi
  
  Background: Periostin, a 90-kDa endogenous extracellular matrix protein, is well known to be involved in the development and persistence of allergic rhinitis. Although histamine H1 receptor antagonists are recommended as first choice of agents in the treatment of allergic rhinitis, the influence of the agents on periostin production is not well understood. The present study was undertaken to examine the influence of histamine H1 receptor antagonists on periostin production from nasal epithelial cells after IL-4 stimulation in vitro. Methods: Human nasal epithelial cells (HNEpC) at a concentration of 1 × 105 cells/ml were stimulated with 10.0 ng/ml IL-4 in combination with either desloratadine (DLT), loratadine (LT), levocetirizine (LCT) or cetirizine (CT). After 48 h, culture supernatants were collected and assayed for periostin levels.. View More»
  DOI: 10.4172/2155-6121.1000253

  Abstract PDF