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Hiroshi Itoh
Hiroshi Itoh
Japan
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Commentary
Bilirubin as a New Biomarker of Diabetes and its Microvascular Complications
Author(s): Takeshi Nishimura, Masami Tanaka, Risa Sekioka and Hiroshi Itoh Takeshi Nishimura, Masami Tanaka, Risa Sekioka and Hiroshi Itoh
Hyperglycemia is the hallmark of diabetes mellitus [DM]; it activates certain biochemical pathways leading to micro- and macrovascular complications in diabetic patients. Moreover, hyperglycemia generates oxidative stress and causes free radicalmediated lipid peroxidation. In turn, the oxidative stress causes endothelial dysfunction, and has been suggested as one of the important mechanisms underlying the onset and progression of diabetic vascular complications. .. View More»
DOI: 10.4172/2161-1009.1000245