Biology and Medicine

Hiroki Yamaguchi

Publications

• Research Article
  Effective Management of Acute Promyelocytic Leukemia with High Risk of Fatal Intracranial Hemorrhage
  Author(s): Hayato Tamai, Satoshi Yamanaka, Hiroki Yamaguchi, Kazutaka Nakayama and Koiti InokuchiHayato Tamai, Satoshi Yamanaka, Hiroki Yamaguchi, Kazutaka Nakayama and Koiti Inokuchi
  
  Although the prognosis of acute promyelocytic leukemia (APL) are favorable because of disease-specific drugs, such as all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), early death due to fatal intracranial hemorrhage has been observed in many cases. The aim of this study is to examine the relationship between the treatment and intracranial hemorrhage complication in APL patients.46 patients diagnosed of APL during a period from 2000 to 2014 in our hospital were examined. The distribution of fatal intracranial hemorrhage (FICH) risk score in the 46 APL patients showed 23.9%, 58.6% and 17.3% for low, intermediate, and high categories, respectively. Among the 46 patients, 5 patients developed intracranial hemorrhage before remission, including 4 patients who developed such hemorrhage after chemotherapy and ATRA administration, and 1 patient who devel.. View More»
  DOI: 10.4172/0974-8369.1000262

  Abstract PDF