Journal of Nanomedicine & Nanotechnology

Hilris Rocha e Silva

Publications

• Research Article
  Surfactant-based Transdermal System for Fluconazole Skin Delivery
  Author(s): Hilris Rocha e Silva, Gabriela Marielli da Luz, Cínthia Yuka Satake, Bruna Carolina Correa, Victor Hugo Vitorino Sarmento, Georgino Honorato de Oliveira, Flávia Chiva Carvalho, Marlus Chorilli and Maria Palmira Daflon GremiãoHilris Rocha e Silva, Gabriela Marielli da Luz, Cínthia Yuka Satake, Bruna Carolina Correa, Victor Hugo Vitorino Sarmento, Georgino Honorato de Oliveira, Flávia Chiva Carvalho, Marlus Chorilli and Maria Palmira Daflon Gremião
  
  The development of a controlled-release dosage form of antifungals is of crucial importance in view of the side-effects of conventional oral and intravenous treatments of Sporotrichosis. In this study, systems composed of polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol (PPG-5-CETETH-20) as a surfactant, oleic acid as an oil phase, and water were developed as a possible fluconazole transdermal drug delivery system. The systems were characterised by polarised light microscopy (PLM), SAXS, and rheological analysis, followed by cellular and histological analyses, in vitro release assays, and ex vivo skin permeation and retention studies using porcine ear tissue and a Franz diffusion cell. PLM and SAXS results indicated that the mixtures of surfactant, oil and water formed micellar and lamellar phases. The incorporation of fluconazole .. View More»
  DOI: 10.4172/2157-7439.1000231

  Abstract PDF