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Heni Rachmawati
Heni Rachmawati
School of Pharmacy, Bandung Institute of Technology,
Ganesha 10, Bandung 40132
Indonesia
Publications
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Research Article
The Influence of Polymer Structure on the Physical Characteristic of Intraoral Film Containing BSA-loaded Nanoemulsion
Author(s): Heni Rachmawati and Bernard Manuel HaryadiHeni Rachmawati and Bernard Manuel Haryadi
Therapeutic protein has limitation, both in stability and invasive route of administration. Therefore, formulation to optimize the use of therapeutic protein becomes the research focus of interest. The purpose of this study was to develop nanoemulsion as a carrier system for a standard-model protein drug – bovine serum albumin (BSA). BSA-loaded nanoemulsion was then formulated into hydrophilic film for intraoral route. The influence of polymers was evaluated in relation to physical property of the film. Nanoemulsion was prepared using self assembly method with composition of Glyceryl monooleate (GMO), Cremophor RH-40 and Polyethylene glycol (PEG 400), with ratio of 1:8:1. The film was prepared using different polymers and plasticizers with solvent casting technique. Standard characterization of BSA nanoemulsion was including droplets size, size distribution, zeta potential, morp.. View More»
DOI: 10.4172/2157-7439.1000187