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Hebeish A
Hebeish A
Egypt
Publications
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Research Article
Utilization of Crosslinked Starch Nanoparticles as a Carrier for Indomethacin and Acyclovir Drugs
Author(s): Gina S El-Feky, El-Rafie MH, MA El-Sheikh, Mehrez E El-Naggar and Hebeish A Gina S El-Feky, El-Rafie MH, MA El-Sheikh, Mehrez E El-Naggar and Hebeish A
An eco-friendly nanoprecipitation technique was put forward to synthesize native starch nanoparticles loaded with insoluble drugs such as indomethacin (IND) and Acyclovir (ACV). Factors studied to find out the optimum conditions for preparation of different formulations of crosslinked starch nanoparticles (TPP-StNPs) loaded with insoluble drugs. The factors are 20 mg, 50 mg of drug concentration and 0.5, 1 g of sodium tripolyphosphate (STPP) while the concentration of starch and surfactant were kept constant. World-class facilities as particle size analyzer, poly dispersity index (PDI), zeta potential, TEM, XRD, FT-IR, UV-vis spectroscopy and DSc were used for evaluation of the resultant crosslinked starch nanoparticles loaded with drug. The sustained release of drugs were evaluated using entrapment efficiency and in vitro release. The data o.. View More»
DOI: 10.4172/2157-7439.1000254