Heba Ahmed Abdelhafez
Egypt
Research Article
N-Terminal Pro-Brain Natriuretic Peptide: Prognostic Potential in End Stage Liver Cirrhosis in a Cohort Free of Heart Failure; an Egyptian Insight
Author(s): Elham Ahmed Hassan, Abeer Sharaf EL-Din Abd El-Rehim, Zain EL-Abdeen Ahmed Sayed, Heba Ahmed Abdelhafez and Muhamad Ramadan Abdelhameed
Elham Ahmed Hassan, Abeer Sharaf EL-Din Abd El-Rehim, Zain EL-Abdeen Ahmed Sayed, Heba Ahmed Abdelhafez and Muhamad Ramadan Abdelhameed
Background: Natriuretic Peptide (NP) system has emerged as one of the most important hormonal systems in control of cardiovascular homeostasis. Liver cirrhosis may affect NP levels that were well described in heart failure. NP prognostic evaluation was well established in many diseases.
Objectives: to measure serum and ascitic NT-proBNP levels in cirrhotic and cardiac Egyptian patients to diagnose a cut-off value for exclusion of heart failure, to assess if cirrhosis per se may contribute in NT-proBNP elevation and to assess the contribution of these levels as predictors of mortality in liver cirrhosis.
Patients and methods: A prospective cohort study was conducted in 80 patients (50 cirrhotics and 30 had heart failure). Serum and ascitic (if available) NT-proBNP were measured. Cirrhotic patients were followed for .. View More»
DOI:
10.4172/2167-0889.1000125