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Heba A. Abou-Taleba
Heba A. Abou-Taleba
Egypt
Publications
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Research Article
Formulation of Novel Glycerin Nanoparticles for Enhancement the Solubility of Loratadine; Application to Transdermal Hydrogel Delivery System
Author(s): Heba A. Abou-Taleba, Mohamed A. El Hamdb and Ahmed A. H. AbdellatifHeba A. Abou-Taleba, Mohamed A. El Hamdb and Ahmed A. H. Abdellatif
Owing to its slightly aqueous solubility, loratadine (LOR) is used in high doses in different marketed formulations to achieve its desirable bioavailability. The aim of this work is to formulate novel LOR-glycerin nanoparticles (LOR-GNPs) to increase LOR bioavailability. LOR-GNPs were prepared by a precipitation method and then evaluated for such size and morphology using dynamic scattering spectroscopy (DLS) and scanning electron microscopy (SEM), as well as the percentage entrapment efficiency (EE%) of free LOR from GNPs formulations was performed using titration method. Furthermore, the GNPs were formulated in hydrogel. The hydrogel viscosity, spreadability, homogeneity and abdominal rat skin permeation were studied and optimized DLS indicated a successful coating of LOR with glycerin surface that recorded an average size of 334 ± 30 nm with uniform particle size, while SEM .. View More»
DOI: 10.4172/2157-7439.1000426