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H. Zia
H. Zia
Tanzania
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Research Article
Enhanced Bioavailability of Fenoterol Transdermal Systems in Rabbits
Author(s): Ahmed Elshafeey, Y.E. Hamza, S.Y. Amin, F. Akhlaghi and H. ZiaAhmed Elshafeey, Y.E. Hamza, S.Y. Amin, F. Akhlaghi and H. Zia
The pharmacokinetic and bioavailability of fenoterol, a B 2 adrenergic agonist were studied to determine the feasibility of enhanced transdermal delivery. Fenoterol has been widely used to treat asthmatic patients. Two fenoterol formulations were studied; the first was a liquid formulation of fenoterol in Transcutol: Oleic acid in a ratio 1:1(F1), while the second was a matrix system of fenoterol in Duro-tak ® 87-2074 adhesive with 10% 1-dodecyl-2- pyrrolidinone as an enhancer (F2). For comparison, control matrix with fenoterol without any enhancer (F3) was also tested. The tested formulations were applied to the shaved back skin of rabbits using HILL TOP CHAMBER ® in case of liquid formula. Blood samples were collected via auricle central vein for 24 hours and the plasma concentrations of fenoterol were determined by LC-MS/MS method. Pharmacokinetic parameters were calculated.. View More»
DOI: 10.4172/jbb.1000067