Journal of Bioequivalence & Bioavailability

Guocai Wang

Publications

• Research Article
  Pharmacokinetic and Pharmacodynamic Study of Terazosin in Healthy Chinese Volunteers: Significant Hysteresis Phenomenon
  Author(s): Guifen Qiang, Man Yang, Yanan Zhang, Man Liu, Dan Zhang, Guocai Wang, Jing Han, Xue Xiao, Zhenlong Wang and Huichen LiuGuifen Qiang, Man Yang, Yanan Zhang, Man Liu, Dan Zhang, Guocai Wang, Jing Han, Xue Xiao, Zhenlong Wang and Huichen Liu
  
  Aim: The present study investigated the correlation between plasma concentration and antihypertensive effect of terazosin in healthy Chinese volunteers. Methods: A randomized, single-dose pharmacokinetic study of 2 mg terazosin hydrochloride tablet was conducted in healthy Chinese male subjects. Supine blood pressure and heart rate were measured before and after dosing, using cardiogram monitor. Serial blood samples were collected and plasma concentrations of terazosin were quantified by high performance liquid chromatography (HPLC) with a fluorescence detector. Non-compartmental pharmacokinetic analysis was applied to plasma concentrations. Results: Plasma concentration of terazosin reached to peak concentration at 0.89±0.62 hours (T max ), and then decreased with half-life value of 10.21±1.41 hours. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) decre.. View More»
  DOI: 10.4172/jbb.1000091

  Abstract PDF