Biochemistry & Analytical Biochemistry

Gulhan Sahin

Publications

• Research Article
  Comparison Of Immunonephelometric And Immunoturbidimetric Methods for Measuring Beta 2-Microglobulin: Fit for Purpose in Routine Clinical Laboratories
  Author(s): Ozlem Goruroglu Ozturk, Sedefgul Yuzbasioglu Ariyurek, Filiz Kibar, Esin Damla Ziyanoglu Karacor, Gulhan Sahin, Gulay Sezgin and Akgun YamanOzlem Goruroglu Ozturk, Sedefgul Yuzbasioglu Ariyurek, Filiz Kibar, Esin Damla Ziyanoglu Karacor, Gulhan Sahin, Gulay Sezgin and Akgun Yaman
  
  Serum free beta 2-microglobulin (b2M) level has been regarded as an independent biomarker in several cancers, and has traditionally been analyzed using methods such as Immunonephelometry on specialized analyzers. It is now possible to perform this test on clinical chemistry analyzers, using immunoturbidimetry. The aim of this study was to compare these two methods, for measuring serum b2M level. Fourty three samples which were randomly chosen from sera of patients with various malignant conditions were analyzed for serum b2M level, both by immunonephelometric method in Beckman Immage 800 (Beckman Coulter Inc., CA, USA) nephelometer, and by immunoturbidimetric method in Beckman UniCel DXC 800 Synchron (Beckman Coulter Inc., CA, USA) auto-analyzer. Method comparison demonstrated good agreement between the immunonephelometric and immunoturbidimetric b2M testing, in which we found good co.. View More»
  DOI: 10.4172/2161-1009.1000119

  Abstract PDF