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Research Article
Similarities and Differences in Cognitive Deficits and Responsiveness to L-Dopa between Aged and MPTP-Treated Cynomolgus Monkeys Tested on the Same Tasks
Author(s): Zhang Z, Weeks R, Grondin R, Wan H, Yue F and Chan PZhang Z, Weeks R, Grondin R, Wan H, Yue F and Chan P
Cognitive and motor declines are two major geriatric problems often coexisting in older adults. Also, mild cognitive impairment (MCI) is frequently observed in patients with Parkinson’s disease (PD) in addition to motor dysfunction. Amelioration of cognitive deficits, either in patients with PD or in senescence, has proven problematic in the clinic; due, in part, to a poor understanding of the mechanism underlying PD-MCI and age-associated cognitive declines. Thus, a better characterization of similarities and differences between age-associated and disease-related cognitive impairments should help better design therapeutic strategies tailored to restore cognitive functions in either the elderly or PD patients. In the present study, eighteen cynomolgus monkeys were trained and tested on a delayed matching-toposition (DMTP) and de.. View More»
DOI: 10.4172/2167-7182.1000188