Journal of Nanomedicine & Nanotechnology

Grinberg I

Publications

• Research Article
  Engineering of New UV-Blocking Hollow Proteinoid Nanoparticles of Narrow Size Distribution Containing All-trans Retinoic Acid for Biomedical Applications
  Author(s): Belostozky A, Kolitz-Domb M, Grinberg I, Haham H and Margel SBelostozky A, Kolitz-Domb M, Grinberg I, Haham H and Margel S
  
  All-trans retinoic acid (at-RA), the most active form of vitamin A, is known to be highly beneficial in dermatology. At-RA can reduce acne vulgaris symptoms and improve the skin appearance significantly. Moreover, at-RA is a useful treatment for different skin diseases and for several types of cancer. However, it is extremely sensitive when exposed to ultraviolet (UV) light, due to conjugated double bonds that comprise its chemical structure. In order to increase the benefits of topical use of at-RA, a new drug carrier encapsulating and protecting at-RA from light-dependent degradation, is designed and presented here. Proteinoids are biocompatible polymers made from amino acids by thermal step-growth polymerization. These polymers form hollow nanoparticles in an aqueous solution by a simple selfassembly process, during which suitable molecules may be encapsulated within the particles... View More»
  DOI: 10.4172/2157-7439.1000462

  Abstract PDF