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Gomma MN
Gomma MN
Jeddah
Saudi Arabia
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Research Article
Brain Biogenic Monoamines in Relation to Brain Histopathology and Plasma Glutathione Shuttle in Rat after Exposure to Sea Anemone Gyrostoma helianthus Extract
Author(s): Al-Hazmi MA, Gomma MN, Waggas AS and Rawi SMAl-Hazmi MA, Gomma MN, Waggas AS and Rawi SM
The extract of sea anemone Gyrostoma helianthus (Cnidaria, Anthozoa) has been reported as a source of neuroactive compounds. The current study was designed to explore biogenic monoamine effects of sea anemone crude extract in relation to histopathological changes in brain areas and plasma glutathione shuttling. Mouse bioassays were used to determine the dose response curve and behavioral neurotoxicity. Loss of balance, opaque eyes, tonic convulsions, paralysis, muscle flexing, and exophthalmia were the major behavioral changes observed. The LD50 in mice was identified as 29 mg/kg body weight after IP injection, which is calculated to be 20.3 mg/kg body weight in rats using a conversion table. Serotonin, dopamine, and norepinephrine were significantly increased in the cerebral cortex, cerebellum and pons plus medulla oblongata in rats in our 3-day study after a single IP injection of &.. View More»
DOI: 10.4172/jbb.1000208