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Geremew Tasew
Geremew Tasew
Ethiopia
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Review Article
Malaria Vaccine Development: Recent Advances alongside the Barriers
Author(s): Desalegn Nega, Abebe Alemu and Geremew Tasew Desalegn Nega, Abebe Alemu and Geremew Tasew
Although malaria control efforts have currently reduced much of the morbidity and mortality, yet malaria remains a hard problem in many parts of Africa. Together with the existing malaria control efforts, an effective malaria vaccine is expected to act as an important weapon to fight against malaria burden. Developing an efficacious malaria vaccine is a top priority in the agenda of global health program. However, the multi-stage life cycle, antigenic variation, and vast genetic diversity of malaria parasites made malaria vaccine development difficult for years. This study was conducted with the aim of reviewing the status of malaria vaccine development through different obstacles in the path. Vaccine trials currently upgraded to yield a partially effective and short-lived immunity with the pre-erythrocytic subunit vaccine, RTS,S/AS01, which is likely to be the first vaccine to be lic.. View More»
DOI: 10.4172/2155-9597.1000300