Biochemistry & Analytical Biochemistry

Garmanchuk LV

Publications

• Research Article
  Influence of Chelidonium majus Water Extract onto Cancer Cells and Platelets
  Author(s): Deulenko VN, Marunych RY, Chernyshenko VO, Rebriev AV, Lugovskoy EV, Garmanchuk LV and Pavliuk OVDeulenko VN, Marunych RY, Chernyshenko VO, Rebriev AV, Lugovskoy EV, Garmanchuk LV and Pavliuk OV
  
  The plant C. majus (Celandine) is a known source of biologically active compounds that are used in traditional medicine for preventing or curing cancer diseases. The growing interest in this plant is due to discovery of a number of plant-derived cytostatics and anti-blastic drugs. The goal of our study was to discover the influence of a water extract from these plants on cancer cells and to characterize the obtained extract using different analytical methods. Water extract of leaves of C. majus were obtained and lyophilized on TelStar LyoQuest (Spain). Composition of the extract was characterized using HPLC Agilent 1100, SDS-PAGE electrophoresis and MLADI-TOF Mass-spectrometry. ADP-induced platelet aggregation in the presence of obtained mixture was studied by aggregometry using Solar2110 (Belorussia). Effects of the extracts on proliferation of cancer cells was estimated using MTT-te.. View More»
  DOI: 10.4172/2161-1009.1000370

  Abstract PDF