Journal of Bioequivalence & Bioavailability

Gagik Bazikyan

Publications

• Research Article
  Na/K Pump α3-Isoform-Dependent Cell Hydration Controlling Signaling System Dysfunction as A Primary Mechanism for Carcinogenesis
  Author(s): Sinerik Ayrapetyan, Liana Yeganyan, Gagik Bazikyan, Rafayel Muradyan and Flora ArsenyanSinerik Ayrapetyan, Liana Yeganyan, Gagik Bazikyan, Rafayel Muradyan and Flora Arsenyan
  
  More than 40 years cell over-hydration serves as a diagnostic marker for carcinogenesis. However, the nature of cell volume controlling mechanism dysfunction of which leads to over hydration and abnormal cell proliferation is not clear yet. The individual roles of Na+/K+ pump isoforms having different affinity to ouabain (α1-low, α2-midle and α3-high affinity) in cell hydration of different organs of healthy (H) and sarcoma-180 tumor (ST) carrying (SC) mice were studied. The tissue hydration in all organs in SC animals was higher. The pathology-induced cell hydration was accompanied by increase in α3 receptors affinity to 3H-ouabain in excitable and decrease in non-excitable cells. 10-11 M ouabain leads to dehydration while 10-8 and 10-6 M to hydration in SC mice, including ST. Tissue hydration in H and SC mice has different sensitivity to anti cancer drug-cisplati.. View More»
  DOI: 10.4172/jbb.1000123

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