Pharmaceutica Analytica Acta

Flávio V Meirelles

Publications

• Research Article
  Structural Analysis of Cyclophilin from Moniliophthora Perniciosa and Inhibitory Activity of Cyclosporin an on Germination and Growth of Fungi
  Author(s): Paulo S Monzani, Humberto M Pereira, Karina P Gramacho, Fatima C Alvim, Flávio V Meirelles, Glaucius Oliva and Júlio CM CascardoPaulo S Monzani, Humberto M Pereira, Karina P Gramacho, Fatima C Alvim, Flávio V Meirelles, Glaucius Oliva and Júlio CM Cascardo
  
  Moniliophthora perniciosa is the causal agent of witches’ broom disease of cacao. Cyclophilins have been implicated in a wide variety of cellular processes, including the response to environmental stresses, cell cycle control, regulation of calcium signaling and transcriptional control. The involvement of cyclophilins in pathogenicity was described both in pathogenic fungi toward animals and plants. In Yeast, calcineurin and cyclophilin are involved in fungal morphogenesis and virulence. There is evidence that cyclophilin interacts with calcineurin in the absence of cyclosporin A (CsA), and it has been proposed that the activity of CsA acts in the regulatory interaction between cyclophilin and calcineurin; also, fungistatic or fungicide actions have been observed in this activity. The M. perniciosa cyclophilin gene from cDNA of the fruiting body in the vector pET28a has been clo.. View More»
  DOI: 10.4172/2153-2435.S7-001

  Abstract PDF