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Fisher D
Fisher D
Singapore
Publications
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Research Article
Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantification of Ertapenem in Human Serum
Author(s): Hee KH, Fisher D, Soon-U Lee L and Tam VHHee KH, Fisher D, Soon-U Lee L and Tam VH
We have developed and validated a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the quantification of ertapenem in serum samples derived from patients with complicated urinary tract infections. Ertapenem was separated on reverse phase C18 column within the analytical runtime of 2 min. Detection and quantification of ertapenem was based on multiple reactions monitoring under positive ionization mode using deuterium-labeled internal standard. The lower limit of quantification of ertapenem in serum was 1 μg/ml. Excellent linearity was demonstrated between 1–200 μg/ml in serum with r2>0.996. Accuracy and precision for the assay in serum were in the range of 96.7–106.5% and 0.59–4.22%, respectively. The developed method is specific with no endogenous co-eluting peaks in serum. Minimal matrix effect was found in serum between 94.9–107... View More»
DOI: 10.4172/2153-2435.1000358