Journal of Carcinogenesis & Mutagenesis

Firdous Hussain

Publications

• Research Article
  Role if ATM IVS10-6T?G Polymorphism in Breast Cancer: A Case-control Study in High-risk Kashmiri Population
  Author(s): Nidda Syeed, Firdous Hussain and Mushtaq A Siddiqi Nidda Syeed, Firdous Hussain and Mushtaq A Siddiqi
  
  The provenance of ATM candidacy as a susceptible breast cancer gene stems from two sources. The main task of ATM being that the ATM protein is a fundamental participant in mediating cellular responses to DNA damage, including cellular signaling, DNA double-strand break repair and leading to cell-cycle arrest and apoptosis. From the genetic standpoint, ATM is a gene mutated in ataxia-telangiectasia (AT), an autosomal recessive disorder phenotypically characterised by chromosomal instability and an increased risk for lymphoproliferative tumors in homozygotes. Numbers of studies have suggested that heterozygous carriers of ATM mutations are at increased risk of breast cancer and ATM IVS10-6T→G SNP has been reported to significantly increase the breast cancer risk. In order to shed further light on the putative contribution of ATM to breast cancer risk, we performed haplotyping of th.. View More»
  DOI: 10.4172/2157-2518.1000163

  Abstract PDF