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Fernando Pires Hartwig
Fernando Pires Hartwig
Brazil
Publications
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Review Article
Up-Regulating Telomerase and Tumor Suppression: A Two-Step Strategy to Boost Hematopoietic Stem Cell Transplantation
Author(s): Fernando Pires Hartwig Fernando Pires Hartwig
The high levels of morbidity and mortality of chronic non-communicable diseases (most of which highly associated with aging) worldwide indicate the need of studying the underlying mechanisms of physiological aging and aging related-impairments and the development and improvement of therapeutic approaches such as cell therapy. In this manuscript, two well-established aging mechanisms – telomere shortening and DNA damage accumulation – are briefly reviewed regarding their roles in hematopoietic stem cells function and transplantation. Based on the available literature, up-regulating both telomerase and tumor suppressors is proposed in a two-step strategy as a promising mechanism to benefit hematopoietic stem cell transplantation qualitatively (by enriching the cell pool for healthy hematopoietic stem cells) and qualitatively (by in vitro expansion of healthy.. View More»
DOI: 10.4172/2157-7633.S3-003